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| Registros recuperados: 2.719 | |
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| Emery,Flávio da S.; Silva,Raphael S.F.; Moura,Kelly C.G. de; Pinto,Maria C.F.R.; Amorim,Mauro B.; Malta,Valéria R.S.; Santos,Regina H.A.; Honório,Kátia M.; Silva,Albérico B.F. da; Pinto,Antonio V.. |
| The reaction of naphthoquinone-oximes (3) and (4) with diazomethane yields directly, in one step, the oxazoles (5) and (6), respectively. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinones; Oximes; Diazomethane; Oxazoles. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100004 |
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| Tavares,Claudinéia R.O.; Bendassolli,José A.; Coelho,Fernando; Sant'ana Filho,Carlos R.; Prestes,Clelber V.. |
| This work describes a method for 15N-isotope-labeled glycine synthesis, as well as details about a recovery line for nitrogen residues. To that effect, amination of alpha-haloacids was performed, using carboxylic chloroacetic acid and labeled aqueous ammonia (15NH3). Special care was taken to avoid possible 15NH3 losses, since its production cost is high. In that respect, although the purchase cost of the 13N-labeled compound (radioactive) is lower, the stable tracer produced constitutes an important tool for N cycling studies in living organisms, also minimizing labor and environmental hazards, as well as time limitation problems in field studies. The tests were carried out with three replications, and variable 15NH3(aq) volumes in the reaction were used... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Stable isotope; Glycine; Amino acid. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000300005 |
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| GONÇALVES,MARIA DA CONCEIÇÃO R.; MIRANDA NETO,MANOEL; CAVALCANTE,ISA G.M.; SEBADELHE,VITTÓRIA R.R.J.; SOUZA,MICHELE F. De; NEVES,JULIANA P.R.; SOUZA,FLAVIA T.L. DE; TAVARES,RENATA L.; COSTA,MATHEUS S.; SILVA,ALEXANDRE S.. |
| Abstract Given the scarcity of studies with elderly and the existence of studies investigating the effect of vitamin D supplementation in PEH (post exercise hypotension), this study evaluated the effect of a single megadose of vitamin D on resting blood pressure (RBP) and post-exercise hypotension (PEH) in the elderly. 11 hypertensive elderly women (70.3 ± 1.7 years) received a single megadose of 200.000 IU of cholecalciferol or a placebo, orally, through capsules. On day 7, the subjects performed 30 minutes of aerobic exercise with blood pressure measurement before exercise and every 10 minutes after exercise during 60 minutes, besides cardiac autonomic modulation. RBP did not significantly change. Exercise promoted significant systolic PEH only in one... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aerobic exercise; Aged; Hypertension; Hypotension; Cholecalciferol. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100903 |
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| MARTINEZ,PABLO D.G.; KRAKE,SUSANN H.; POGGI,MAITIA L.; CAMPBELL,SIMON F.; WILLIS,PAUL A.; DIAS,LUIZ C.. |
| ABSTRACT Combination therapy drugs are considered a fundamental way to control malaria as it mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently, this type of therapy constitutes a driving force for the discovery of new drugs with different modes of action, since this will provide options for combining different drugs to achieve the optimum antimalarial treatment. In this context, a 2,3,8-trisubstitued quinoline compound was found in a high throughput screen (HTS) to show an excellent inhibition of P. falciparum NF54 (IC50 = 22 nM) and low cytotoxicity. We performed a detailed evaluation of the substituents to improve the metabolic stability and solubility liabilities of the original hit and identified derivatives... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimalarial activity; Trisubstituted quinoline; SAR; Resistance. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301215 |
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| Gomes,Urubatã E.; Oliveira,Diogo L. de; Berti,Luciana C.; Amaral,Olavo; Souza,Diogo O.; Wofchuk,Susana T.. |
| Scientific activity in Brazil has experienced an accelerated growth in the past decades, with an increase in productivity that greatly surpasses the international average. This growth has occurred mostly at the expense of centers of excellence in public universities, which account for the vast majority of the country's scientific output. The aim of this study was to evaluate the production of the Department of Biochemistry of a large public university in southern Brazil (Universidade Federal do Rio Grande do Sul), as well as to identify internal and external policies that have influenced this growing production profile. We have performed a historical analysis of the scientific output of this Department of Biochemistry, which accounts for a considerable... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scientific productivity; Scientific growth profile; Biochemistry; UFRGS. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300030 |
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| VASCONCELOS,PAULO M.; ONOE,ARTUR T.; KAWASHITA,KOJI; SOARES,ADALBERTO J.; TEIXEIRA,WILSON. |
| Laser heating 40Ar/39Ar geochronology provides high analytical precision and accuracy, mum-scale spatial resolution, and statistically significant data sets for the study of geological and planetary processes. A newly commissioned 40Ar/39Ar laboratory at CPGeo/USP, São Paulo, Brazil, equips the Brazilian scientific community with a new powerful tool applicable to the study of geological and cosmochemical processes. Detailed information about laboratory layout, environmental conditions, and instrumentation provides the necessary parameters for the evaluation of the CPGeo/USP 40Ar/39Ar suitability to a diverse range of applications. Details about analytical procedures, including mineral separation, irradiation at the IPEN/CNEN reactor at USP, and mass... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Geochronology; 40Ar/39Ar method; Irradiation; Calibration. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200008 |
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| Souza,Eleane M.C. de; Silva,Ellon L. Da; Marinho,Andrey M.R.; Marinho,Patrícia S.B.. |
| The present work reports the isolation of eight compounds fromPestalotiopsis sp. EJC07 isolated as endophytic fromBauhinia guianensis, a tipical plant of the Amazon. The compounds (4S)-4,8-dihydroxy-1-tetralone (1), uracil (2), uridin (3), p-hydroxybenzoic acid (4), ergosterol (5), ergosterol peroxide (6), cerevisterol (7) and ducitol (8) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS. The compound 1 is being reported for the first time in the genusPestalotiopsis. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: B. guianensis; Endophityc fungus; Pestalotiopsis; Tetralone. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100029 |
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| HOU,CHUN; MIAO,YONG; JI,HANG; WANG,SUSHENG; LIANG,GANG; ZHANG,ZHIHUA; HONG,WEIJIN. |
| ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MMP2; MMP9; 6-Gingerol; Hair growth. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602707 |
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| ALMEIDA,MACIA C.S. DE; SOUZA,LUCIANA G.S.; FERREIRA,DANIELE A.; PINTO,FRANCISCO C.L.; OLIVEIRA,DÉBORA R. DE; SANTIAGO,GILVANDETE M.P.; MONTE,FRANCISCO J.Q.; BRAZ-FILHO,RAIMUNDO; LEMOS,TELMA L.G. DE. |
| ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bauhinia pentandra; Fabaceae; Cyanoglucoside; Lactones; RMN.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100065 |
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| Oliveira Neto,Osmundo B.; Farias,Davi F.; Vasconcelos,Ilka M.; Paes,Norma S.; Monteiro,Ana C. S.; Silva,Maria C. M. da; Guimarães,Luciane M.; Carvalho,Ana F.U.; Grossi-de-Sá,Maria F.. |
| Chagasin may be considered a potential plant-incorporated protectant (PIP) protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein + r-chagasin (0.25, 0.5 and 1% of total protein) were offered to rats (10 days). The test diets did not show adverse effects upon the development, organ weight, hematological parameters and serum protein profiles of rats, providing preliminary information on the safety of r-chagasin. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chagasin; Recombinant protein; Hazard potential; Short-term rat feeding trial. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100019 |
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| SILVA,RAQUEL B.; SILVA-JÚNIOR,EDVALDO V.; RODRIGUES,LAÍS C.; ANDRADE,LAISE H.C.; SILVA,SUZENE I. DA; HARAND,WOLFGANG; OLIVEIRA,ANTONIO F.M.. |
| In this study, pulp and kernel of fruits from six Arecaceae species were subjected to proximate analysis, fatty acid composition and total carotenoid content analysis. The species with the highest carbohydrate, lipid and protein values were Ptychosperma macarthurii(70.1 g/100 g in the kernel), Syagrus cearensis(40.6 g/100 g in the kernel), andS. coronata(20.6 g/100 g in the pulp). The ash content ranged from 0.61 to 7.51 g/100 g. Lauric, palmitic, and oleic acids were the major fatty acids identified. The total carotenoid contents and retinol activity equivalents were highest in the Pinanga kuhlii (180.3 µg/g) andAcrocomia intumescens (138.0 µg/g) pulp oils. Retinol activity equivalents varied between the investigated species (456 to 1515 μg RAE/100 g).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biomass; Foods; Oleic acid; Palm trees. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401701 |
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| J. SIMÃO,MARIELA; J.S. BARBOZA,THIAGO; G. VIANNA,MARCELA; GARCIA,RENATA; MANSUR,ELISABETH; P.R. IGNACIO,ANA CLAUDIA; PACHECO,GEORGIA. |
| Abstract Passiflora species are well known for their common use in popular medicine for the treatment of several diseases, such as insomnia, anxiety, and hysteria, in addition to their anti-inflammatory, antioxidant, analgesic and antibacterial potential. However, few data about the chemical composition and the medicinal potential of in vitro derived materials are available. Therefore, the goal of this work was to compare, for the first time, the phytoconstituents of in vitro derived materials of four Passiflora species, and evaluate the antibacterial potential of their extracts against 20 Gram-positive and negative strains. Chromatographic analysis indicated the presence of saponins in roots extracts from all studied species, whereas leaf extracts... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antibacterial; Chromatography; Flavonoids; Passiflora; Saponins. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602805 |
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| Registros recuperados: 2.719 | |
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